This Thematic Line focuses on the analysis of urban morphology and the operational rationale and structuring of territorial and urban metabolisms, as well as the cross-cutting theme of sustainability. Given the interdisciplinary vocation of the urban metabolism term, this should be used as a concept to bridge perspectives and build collaborations across different strands of research on environment, territory and cities. Both urban and rural realities are assumed as a strategic dynamic and transversal factor for the development of the territories of the future.